Fiaud’s Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential

(S, S)-1-hydroxy-1-oxo-2-c,5-t-diphenylphospholane or Fiaud’s acid is used as a novel and effective chiral organocatalyst for bis α-aminophosphonates synthesis with excellent diastereoselectivity yields within short reaction time. All synthesized revealed good to antifungal capacity, where the six compounds 4a, 4b, 4e, 4h, 4k 4l are best fungicide inhibiting growth of Fusarium oxysporum Botrytis cinerea by 65% 84% IC50 values <0.02 mg/mL. Similarly, these products exhibited strong antioxidant effect, whereas low inhibition activity was obtained both AChE BChE. Furthermore, they displayed very weak inhibitory against tyrosinase except compound 4l. These findings suggest possible use synthetic pesticides less hazardous effects antioxidant, anti-tyrosinase properties.